Escribá.Įnergy metabolism PC/PE ratio Phosphatidylcholine Phosphatidylethanolamine.Ĭopyright © 2017 Elsevier B.V. This article is part of a Special Issue entitled: Membrane Lipid Therapy: Drugs Targeting Biomembranes edited by Pablo V. To access more functions, click on the Jmol logo in the corner of the structure area for a pop-up menu. Use buttons and controls next to or below the molecule to change the display. We highlight data showing that changes in the PC and/or PE content of various tissues are implicated in metabolic disorders such as atherosclerosis, insulin resistance and obesity. To identify an atom, let the mouse cursor rest on top of it for a few seconds. In mitochondria, changes in the PC/PE molar ratio affect energy production. The relative abundance of PC and PE regulates the size and dynamics of lipid droplets. For example, inhibition of hepatic PC synthesis impairs very low density lipoprotein secretion and changes in hepatic phospholipid composition have been linked to fatty liver disease and impaired liver regeneration after surgery. Abnormally high, and abnormally low, cellular PC/PE molar ratios in various tissues can influence energy metabolism and have been linked to disease progression. The purpose of this review is to highlight the unappreciated impact of phospholipid metabolism on health and disease. The phospholipids are very important structural components of all cell membranes including those of the cell organelles. Phospholipids are a very important class of lipids containing phosphorous bound in a diester linkage. In recent years, the importance of phospholipid metabolism in regulating lipid, lipoprotein and whole-body energy metabolism has been demonstrated in numerous dietary studies and knockout animal models. ADVERTISEMENTS: The below mentioned article provides an explanatory note on the structure of Phospholipids. In the 1950s, Eugene Kennedy and co-workers performed groundbreaking research that established the general outline of many of the pathways of phospholipid biosynthesis. Phosphatidylcholine (PC) and phosphatidylethanolamine (PE) are the most abundant phospholipids in all mammalian cell membranes.
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